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Onuma et al. (2010) analyzed the GCKR SNP rs780094 in 488 Japanese patients with type 2 diabetes and 398 controls and found association between a reduced risk of T2DM and the A allele (odds ratio, 0.711; p = 4.2 x 10(-4)). A metaanalysis with 2 previous association studies (Sparso et al., 2008 and Horikawa et al., 2008) confirmed the association of rs780094 with T2D susceptibility. In the general Japanese population, individuals with the A/A genotype had lower levels of fasting toenail fungus pictures and symptoms plasma glucose (see 613463), fasting plasma insulin, and HOMA-IR than those with the G/G genotype (p = 0.008, 0.008, and 0.002, respectively); conversely, those with the A/A genotype had higher triglyceride levels than those with the G/G genotype (p = 0.028). News

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